Equine Sports Medicine and Regenerative Therapies

Regenaflex™-RT

Regenaflex™-RT is a next -generation stem cell therapy. Regenaflex is a regenerative matrix with a full spectrum of biologically active factors including growth factors, miRNA, exosomes, extracellular vesicles, cytokines, growth and tissue inhibitors of metalloproteinases (TIMPs), as well as healthy extracellular matrix to enhance tissue regeneration and reduce scarring.

Regenaflex is a Regenerative Therapy product made from birth tissues of horses foaling in equine hospitals. After aseptic processing, Regenaflex-RT is a room temperature, shelf-stable product that can be used immediately on the farm.

Regenaflex has demonstrated the ability to: accelerate and improve the quality of healing, reduce pain and inflammation, and improve blood supply resulting in repairs with less scarring and thereby less chance of re-injury compared to other therapies

Mechanism of action in this regenerative matrix is related to a full spectrum of growth factors, miRNA, peptides, and exosomes. This provides all the factors in the regenerative orchestra needed for tissue regeneration and to activate the intrinsic reparative processes of damaged tissues. It also possesses antimicrobial properties, and an extracellular matrix that can serve as a scaffold for cell proliferation and differentiation.

Regenerative medicine 2.0: extracellular vesicle–based therapeutics for musculoskeletal tissue regeneration

  • Extracellular vesicles have emerged as prominent mediators of homeostasis, repair, and regeneration of musculoskeletal tissues such as bone, skeletal muscle, and cartilage
  • Extracellular vesicles and exosomes as alternatives to mesenchymal stromal cells that are liable to self-replicate
  • Exosomes can be more readily manipulated to display specific surface proteins for enhanced tissue targeting
  • The ability to manipulate exosomes and tissue-homing properties to achieve predictable and specific biological effects can be harnessed for the development of precise and customizable therapeutics

For More Information: https://hilltopbio.com/horse-owners/

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Written By

MARK MEDDLETON, DVM

Dr. Mark Meddleton, DVM is a 1991 graduate of Cornell University, and a 1992 graduate of a Medical and Surgical Internship at the University of Minnesota. He is a member of the American Association of Equine Practitioners (AAEP), the International Society of Equine Locomotor Pathology (ISELP), and the American Veterinary Chiropractic Association (AVCA) and has been performing Animal Chiropractic since 1994. He has also extensively studied Equine Dentistry.